Some new information on why Amitriptyline works:
http://psychcentral.com/news/2009/06...tors/6761.html
Quote:
Doctors also prescribe amitriptyline for chronic pain such as migraine headaches or the nerve damage caused by diabetes, he notes.
In laboratory tests, amitriptyline could protect neurons from oxygen and glucose deprivation or the toxin kainic acid. Only amitriptyline, and not other antidepressants, could duplicate NGF’s ability to stimulate neurons to send out “neurites,” small projections thought to be the beginnings of connections to other neurons.
Amitriptyline directly binds TrkA and a related molecule called TrkB, the authors found. Amitriptyline could also bring together a mismatched pair of TrkA and TrkB — a phenomenon not seen before, Ye says.
Also surprising was the finding that other tricyclic antidepressants — even those with a similar molecular structure such as imipramine — could not match amitriptyline’s ability to stimulate cells through TrkA.
In a model of antidepressant function called a “forced swim test,” amitriptyline’s effects do not depend on TrkA, because it still works on mice with modified TrkA genes, the authors found.
The results are published online and appear in the June 26 issue of the journal Chemistry & Biology.
|
So it looks here like Elavil (amitriptyline) is the drug of choice now.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.