Quote:
Originally Posted by lady_express_44
You gotta be quick to catch anything on the internet about PML and Tysabri  .
Not sure if the links are working for others, but here's the breakdown:
Progressive multifocal leukoencephalopathy (PML):
In the period between the reintroduction and approval of TYSABRI in July 2006 and June 26, 2009, the following cases of PML have been confirmed:
June 23, 2009 30 months MS Ex-US
June 19, 2009 34 doses MS Ex-US
June 10, 2009 35 doses MS Ex-US
May 18, 2009 24 doses MS US
April 15, 2009 31 months MS Ex-US
February 5, 2009 12 months MS Ex-US
December 10, 2008 26 months MS Ex-US
October 29, 2008 14 doses MS US
July 31, 2008 14 months MS Ex-US
July 30, 2008 17 months MS Ex-US
Cherie |
Just to make the details better I've converted doses to months with the help of the detailed PML case summary
Ex-US Cases
Jul 30, 2008 - 17 months started Feb 07
Jul 31, 2008 - 14 months started May 07
Dec 10, 2008 - 26 months started Oct 06
Feb 5, 2009 - 12 months started Feb 08
Apr 15, 2009 - 31 months started Sep 06
Jun 10, 2009 - ~32 months started Nov 06
Jun 19, 2009 - ~31 months started Oct 06
Jun 23, 2009 - 30 months started Jan 07
US Cases
May 18, 2009 ~ 22 months started July 07
Oct 29,2008 ~ 13 months started Sep 07
Notice the clustering of cases in the group of Ex-US patients who started between Sep 06 and Feb 07. 6 out of the 8 cases.