i konw how you feel.i took reg mest,tapering up slowly to 60-90 mgs every 6 hrs. i had horrible spams including my stomach which then made me vomit. we sat and just laughed watching my face and ars twitching away!! dr then put me on time rel mest starting again slowly at 90 mgs bid then increasing slowly when i felt ok. i took the second 1/2 at lunch time and had no issues. i also took 60 mg reg mest last week 3 times[daughter moved etc] and the spasms started immed ,taking 180 mg of time rel mest made my stomach ache .not too bad but the time rel ismuch better for me. they want to start me on imuran but i will wait until the fall. vacation is coming up, i'm going to be a gramma in aug,we have a wedding in new york in aug etc. i do not want to screw up the summer with sideeffects since we only get one a year since i was disabled 8 yrs ago from another illness. maybe you could try ths time rel also taper up slowly is the best thing to do. have a good w/e!!