Linda, I understand what you said, "it is very strange how one day the meds work well and then another they do nothing for me." This happens to me also. With the Provigil I still have to rest but am wakeful for 3-4 hours at a time more so than just the 2-3 hours. Also, I drink coffee all day and it helps me to keep awake. When I feel achey, usually my ribcage area, I rest and use a heat pad. I also take extra strength tylenol once in awhile. REST is the key for me. I have also noticed with Provigil I do not always have to take my 1 1/2 tablets of Mestinon every 3 hours. I can stretch it to sometimes 5 or 6 hours. I also notice that I may have to take a 1/2 tab more of the Provigil. I only take 1 now.

Hang in there lady, every day is a new day! Best wishes.

Cindy