Hi Xmas25,
What quantity of Timespan do you take per day?
I'm not sure about Timespan, but with regular 60 mg Mestinon, I would increase the frequency, i.e. each 3hrs instead of each 4hours… I assume that one should have in the body a constant quantity of active product throughout the day, so smaller doses more frequently should be better than higher doses less frequently.
Mestinon intake could (should?) also vary according to individual's muscular activities, high activity, higher doses…
Personnally, I often felt when I was in need (again with regular Mestinon), so I was able (and allowed by my neuro) to adjust my intake. Too much Mestinon was more difficult to detect, only when I forgot to take it, I noticed that I could stay longer without taking it!
Good luck!
Maurice.