I'm on my second flare since April and just had a Bier Block that didn't work. I have one leg that is the worst of all extremities, but i have RSD on both legs and boths arms and I feel like it might be spreading to my face.

Now my PM prescribed Naltrexone 4.5 mg in addition to Topomax and Despiramine (Norpramin). I have been on Cymbalta (60mg BID) and Mexiletine (total of 1200 mg/daily) but the Mexiletine stopped working.

The Dr. said the Naltrexone is still experimental but with low to no side effects. I don't do well adjusting to new meds and it takes me an avg of 2 months to feel as if i can function again. So I am nervous starting multiple ones at the same time.