Dejibo,

I just had my 28th infusion. I rarely think about PML. If any new or worsening symptoms crop up, I'm to notify the neuro so that they can rule out PML. I haven't had any new symptoms other than the tiredness I usually feel for a day or two following the infusion.

I previously took Avonex, Rebif and Copaxone and I feel the best by far on Tysabri. I even had an improvement in symptoms which I didn't expect to really happen. The TOUCH process can be a bit difficult in the beginning, especially when dealing with Biogen (at least in my experience). I was on them all the way through the initial process though and if they missed information, I corrected them immediately and got them to fix it and verify with my neuro's office.

Good luck with getting started on Tysabri if you do decide to make that decision.