I feel like this thread was aimed at me! Thanks, CS.

I've been on Mirapex 0.75 mg and 100/25 Sinemet CR three times a day for nearly two years now. For the last couple of months, I'm noticeing that they take about an hour to kick in, last for about 3 hrs. and then don't seem to be working. So I'm left with feeling stiff and "gimpy" the middle and end of my working day. Overtime is a waste of time.

I see my MDS the end of Jan. I'm seriously considering stopping work and going on disability, I just don't feel competent and safe anymore, plus I have no energy after work to do anything else. The thought of not working is scary and appealing at the same time. I've been a physical therapist for nearly 35 years and have loved my job until recently.

I was diagnosed five years ago, about a year after I noticed tremor, incoordination, and a limp. I"m 54.

Any suggestions and/or information very much appreciated.!