Dear Abbie,
The SSRIs can stop working I think -- it has not been my experience because I have not taken them -- in the literature it is sometimes called "Prozac Poop-out."
http://depression.about.com/od/resistance/f/poopout.htm
Quote:
Although it's most commonly referred to as "Prozac Poop-out", it can actually occur with any SSRI. What it refers to is a phenomenon where the patient's antidepressant simply stops working. This problem affects anywhere from 10-50%--depending who you ask--of all SSRI users.
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According to the article:
Sometimes a second drug works.
Sometimes rotating off on more than one drug works.
Going off a drug for a while and then going back on it works.
M.