Yes, indeed.

Even though Cymbalta is not an SSRI precisely, it has many of the same characteristics. It's efficacy is attributed to the reuptake inhibition of serotonin and noradrenaline, so is sometimes classed as an SNRI (or SSNRI), along with Effexor. Both drugs also have a mild effect on dopamine reuptake.

Any drug really can poop out... our receptors simply get "accustomed" to the molecule and become less and less responsive to it.

But it is in fact well documented as per Mari's post above, with SSRI drugs, so, after five years (a long time) it does not surprise me that Cymbalta, a related drug, would fall short in the same way.

i hope the pdoc can come up with some novel ideas!



~ waves ~