Smoke,,,,,,,,,,,,you can go to mayo clinic.com or drugs.com or medicinenet.com or ask your dr or read the paperwork that comes with the meds or punch the info into any internet engine , they can cause liver toxcity,,induced hepatits on the liver,,,serious and fatal liver disease[quote],, the meds like percocet and vicoden are dangerous because they are stacked with aceaminophen,which perpells the oxycodone or hydrocodone,, even oxy or hydrocodone alone isnt good on the liver,its even worse when the dose is upped or stacked with muscle relaxents and other meds,,cymbaltra is hard on the liver too,,,smoke,,,i take them too,,im just giveing you the info you asked for,,i have a sensitive liver ,,i just wouldnt want or wish it on anyone here,everything taken with moderately is ok,,but long term or high doses isnt,,,your buddy not foe,,,bobber,,,,