Cooley, There are so many variables here that can affect the results of those tests. These are conditions under which the test may be negative:

• If you have an IgG subclass deficiency. MG Antibodies are IgG. Celiac Antibodies are IgA. Each autoimmune disease has it's own little immunoglobulin.
• If you have been on caffeine, though no studies have "proven" that. Caffeine is a cholinesterase inhibitor, just like Mestinon is.
• If you are at the beginning of the MG process.
• If you are on or have been on Mestinon in the past two weeks. Recent studies show that the effects of Mestinon last longer, after it has worn off (which is only a matter of hours). Mestinon has also been shown to suppress the humoral immune system, which produces antibodies. It acts as a immune regulator.
• If you are on any immunosuppressant drugs, and that includes things like Flovent and Advair.

MG is a clinical disease which is backed up with test results. A negative Acetylcholine Receptor Antibody Test does not mean you don't have MG. Did they run the MuSK Antibody Test? They are working on finding other antibodies that may be involved in MG too.

Did they do an EMG or Single Fiber EMG? RNS? Tensilon Test?

A response to Mestinon, especially over time, is indicative of MG.

An MG expert would not rule out MG based on negative antibodies.

Does anyone ever get tired of this nonsense? Why don't doctors, the ones with "real" medical degrees, get this stuff?

Annie