Even with something as minute as LDN, people have differences in efficacy and tolerance. It really stands to reason that they would with most any drug.

However, the problem is that these drugs don't really have a way to measure their effectiveness. If a person dropped to 1/2, how would they know if this had a negative impact on efficacy?

Copaxone has undergone 2 small studies at 1/2 dosage, and was proven equally effective ... and Rebif is basically just twice the dosage of Avonex, with statistically EQUAL efficacy rates. It wouldn't surprise me if 1/4 or 2 times the dosage would give a similar efficacy rates, to be honest.

It's always just a crap shoot, isn't it?

Cherie