I found these interactions between Prozac and Elavil.
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2 potential interactions were found for the drugs you selected.
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* Elavil
* Prozac
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(Note: Not all drug interactions are known or reported in the literature, and new drug interactions are continually being reported. This information is provided only for your education and for you to discuss with your personal healthcare provider. )
FLUOXETINE (in Prozac) may interact with AMITRIPTYLINE (in Elavil)
Both fluoxetine and amitriptyline have an effect on serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, and anxiety. In rare cases, high levels of serotonin in the brain may cause severe complications like seizures, stroke, and even death. If these drugs are used together, your doctor may want to monitor you closely when therapy with fluoxetine is started or stopped. If you are experiencing problems, it may be necessary to adjust the dose of amitriptyline or to stop therapy with either drug. Discuss this potential interaction with your healthcare provider at your next appointment, or sooner if you think you are having problems.
This interaction is well-documented and is considered moderate in severity.
Last Updated: December 2003
FOOD may interact with AMITRIPTYLINE (in Elavil)
Foods that have a high fiber content may interfere with the absorption of amitriptyline from the stomach. As a result, less amitriptyline would be available for the body to use and blood levels could become too low. This could make the drug less effective. High fiber foods include fruits, vegetables, and grains (bread, cereal, rice, and pasta). Let your doctor know if you have recently changed your diet to include more high fiber foods while you are taking amitriptyline. If the amitriptyline does not seem to be working properly, it may be helpful to adjust your diet. You may want to ask your healthcare provider about this potential interaction if you think you are having problems.
This interaction is poorly documented and is considered moderate in severity.
Last Updated: December 2003
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from
http://www.drugdigest.org/DD/Interac...22+&CheckFDA=1
Also, fluoxetine impairs the clearance and metabolism of amitriptyline.
If the dose of amitriptyline is low, say 10 or 25mg, the effect is not startling.
But if your amitrip. is 50mg or 75mg or 100, this then become significant.
Increasing tricyclic doses, may have an effect on QT times for the heartbeat.
And some people are very sensitive to this.
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Steady-state kinetics of fluoxetine and amitriptyline in patients treated with a combination of these drugs as compared with those treated with amitriptyline alone
A el-Yazigi, K Chaleby, A Gad, and DA Raines
The steady-state kinetics of amitriptyline (AMI), fluoxetine (FLU), and their active metabolites nortriptyline (NTRIP) and norfluoxetine (NFLU) were studied in 15 patients treated once daily for long durations with 50 mg of AMI and 20 mg of FLU. These compounds were analyzed simultaneously in plasma by liquid chromatography. The means and (SEM) of the steady-state concentrations (Css) of AMI, NTRIP, FLU, and NFLU were 80.6 (14.2), 52.6 (10.3), 85.3 (16.1), and 90 (13.6) ng/mL, respectively, and the apparent oral clearances (CLor) of AMI and FLU were 42.4 (8.6) and 14.9 (2.5) L/hr, respectively. The metabolite/drug steady-state concentration ratio (Css(m)/Css) for NTRIP/AMI was 0.75 (0.14) and for NFLU/FLU was 1.27 (0.17). There was a significant correlation (P < 0.05) between Css of FLU and that of AMI or NTRIP. The Css and Css(m)/Css values obtained for AMI were higher (P < 0.056 and P < 0.0034, respectively) than those we observed in 10 patients treated solely with the same dose of AMI. The twofold increase in Css of AMI and ninefold increase in Css of NTRIP seem to be the result of inhibition of the metabolism of these compounds by FLU, particularly the ring hydroxylation. Norfluoxetine may have a small inhibitory influence on the metabolism of NTRIP but lacks this effect on the metabolism of AMI.
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from
http://jcp.sagepub.com/cgi/content/abstract/35/1/17
Are you taking other drugs? Neurontin, Lyrica, Topamax all have side effects, like you describe.
The process of Fibro also creates a type of brain fog, itself. Since studies have shown patients with Fibro have low spinal fluid content of B12, use of
B12 orally may help.
http://www.immunesupport.com/healthw...8/98sum003.cfm
To lower homocysteine, the vitamins B6 and folic acid are needed too.
Please visit our Vitamin forum here for more information.
Brain fog is a common symptom also for B12 deficiency. You can have a serum B12 run, by the doctor as well. (they do not normally do spinal taps except in research studies).
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