Hi, BW & Stari - excuse typing - bad tremors today. Metanx helps improve circulation by increasing endogenous nitric oxide; improves/restores protective sensation and vibratory sensation in pts. with diabetic peripheral neuropathy; metabolizes homocysteine in pts. w/ chronic lower-extremity ulcerations and restores wound healing processes; helps to improve sensation by increasing blood flow & supporting neurofunction as myelinogenesis; for diabetic patients experiencing numbness, tingling and burning sensations in feet. Hope this helps. billie