I really don't know what to say to you about your despondency because those of us who have had this disease for years have learned to not count on something still in the trial stage.

There are at least a handful of other drugs for SPMS in the trial stages which may be helpful at some point in time. Once I read about these drugs I tend to ignore them until some new info is out on the trials. So far everything has bombed, which is why I don't count on anything happening soon that will make me better.

It is my opinion that a drug that will REALLY help will not come into play until the basics behind disease causation is found. There are tons of beliefs out there as to what may cause MS, but so far only abstract theories exist not scientific certitudes.

The only drug I have seen discussed for SPMS patients that appears to help is LDN. There is some info on this board about LDN, so it might be a place for you to research the drug.

You may have a long road ahead with minimal treatment, as many of us do, so figuring out how to remain sane through your life will be the biggest contribution that you can make to your well being.

gmi