4-AP (pardon me while I hijack this thread a moment Jim) Brand name Fampridine, not FDA approved but available from a compounding lab with Dr.'s prescription, A neuro thing that helps some, not others (Me in particular). Also sold as a bird poison (as I affectionately called it) which works by attacking bird's nervous system. It made me tired (others may get hyper & anxious) and "dis-connected. I was glad to discontinue when it didn't work.
Back to Jim's thread. I too had hopes for Mbp8298 and followed your thread with great interest than heard the news. Rituxin trial failing made me sad too.