limpia, is your son on autism spectrum? Just curious, 'cause my son is. You'll probably find more info. if you look in autism areas online. I'm running out of time here tonight, and must go, but I found some info. from Cade. The one I was looking for I just can't find right now, but it's probably there somewhere. (he is the person who invented Gatorade??? -- Dr. Robert Cade at the University of Florida, Gainesville)
Anyway, here's a little of what I found. I didn't come across any mention of Tourette Syndrome in what I have been sifting through right now. Many references to his work, but a little difficult to find.
http://aut.sagepub.com/cgi/content/abstract/3/1/67
more articles by Privett and Sun on that page too.
Autism, Vol. 3, No. 1, 67-83 (1999)
DOI: 10.1177/1362361399003001006
© 1999 The National Autistic Society, SAGE Publications
ß-Casomorphin Induces Fos-Like Immunoreactivity in Discrete Brain Regions Relevant to Schizophrenia and Autism
Zhongjie Sun
J. Robert Cade
Melvin J. Fregly
R. Malcolm Privette
Quote:
The induction of Fos-like immunoreactivity (FLI) was used to determine the brain localization affected by b-casomorphin-7 (b-CM7). Peripheral administration of human b-CM7 at different doses (5, 10 and 30 mg/kg, IV for 1 hour) to rats induced moderate to strong FLI in discrete brain regions including the nucleus accumbens, caudate putamen, ventral tegmental and median raphe nucleus, and orbitofrontal, prefrontal, parietal, temporal, occipital and entorhinal cortex. All of the above areas have been shown to be altered either functionally or anatomically in patients with schizophrenia, and most have been shown to be functionally abnormal in autism. Some of these brain areas are originators or components of dopaminergic, serotoninergic and GABA-ergic pathways, suggesting that b-CM7 can affect the function of all of these systems. The role of some other affected areas in emotional and motivated behavior, social adaptation, hallucinations and delusions suggests that b-CM7, which was found in high concentration in the CSF, blood and urine of patients with either schizophrenia or autism, may be relevant to schizophrenia and autism. Induction of FLI in the above brain areas by a moderate dose (10 mg/kg) of b-CM7 was attenuated significantly, or blocked, by pretreatment with naloxone (2 mg/kg, IP). It is concluded that human b-CM7 can cross the blood-brain barrier, activate opioid receptors and affect brain regions similar to those affected by schizophrenia and autism.
Key Words: autism • brain • casomorphin • Fos • gene • naloxone • schizophrenia
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Cade R, Privette M, Fregly M, Rowland N, Sun Z, Zele V, Wagemaker H, Edlestein C: Autism and schizophrenia: intestinal disorders. Nutritional Neuroscience 3: 57-72, 2000. [No abstract available]
Protein uptake expressed as increased IgA antibodies against food proteins in serum is also increased in coeliac disease and is also found in autistic children (Reichelt et al., 1990 and 1991; Lucarelli et al., 1995; Cade et al., 2000)
http://www.awares.org/conferences/sh...0&full_paper=1
Autistic syndromes and diet : a reasonable connection
Full paper
Biology
Dr Karl Reichelt
University of Oslo, Norway
Might be something more in Neurodiversity. Out of time here... gotta dash.
http://www.neurodiversity.com/psychosis
http://www.neurodiversity.com/biomedical.html
Good search page.
http://www.google.com/search?hl=en&l...hin+induces%22