I have been on the Pristiq for about 3 weeks "this time". I have taken it several times before and was on Effexor XR for a long time. Effexor is a good antidepressant but it makes me really mean. I had to stop taking it. The Pristiq only gives me headaches occassionally but its not bad.
The hard part about having several issues is finding a drug combination that will treat each issue effectively.