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Old 08-13-2009, 08:05 AM
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reverett123 reverett123 is offline
In Remembrance
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
reverett123 reverett123 is offline
In Remembrance
reverett123's Avatar
 
Join Date: Aug 2006
Posts: 3,772
15 yr Member
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Let me think a minute...
We have multiple limiting factors-
Number of roads / dendrites
Number of shuttles / dopamine supply

There is no limit on passengers because the other bottlenecks kick in well in advance. So we want to max out the number of shuttles at any one time.

When we come in to the office in the morning, it takes a little time to get shuttles out the door and onto the roads. During this phase, extra dopamine helps becaue the roads are clear. But as the roads fill, the shuttles have to line up at the gate and watch for a chance to merge into the traffic. In this phase additional shuttles do no good. In fact, it might make it worse. But as things fluctuate the line of shuttles drops and more gaps open up. During this phase, extra dopamine can be used and more shuttles hit the road.

So long as we keep buying shuttles our benefits are limited. If we could find a way to build more roads, however....


Quote:
Originally Posted by AnnT2 View Post
I think you may be on to something. By the way, I love your metaphor, but why then would putting extra cars (dopamine) help the situation even fleetingly (as Sinemet does)? If it is the pathways transporting the cars or dopamine that cause the problem, things would just get more jammed.

Ann
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Born in 1953, 1st symptoms and misdiagnosed as essential tremor in 1992. Dx with PD in 2000.
Currently (2011) taking 200/50 Sinemet CR 8 times a day + 10/100 Sinemet 3 times a day. Functional 90% of waking day but fragile. Failure at exercise but still trying. Constantly experimenting. Beta blocker and ACE inhibitor at present. Currently (01/2013) taking ldopa/carbadopa 200/50 CR six times a day + 10/100 form 3 times daily. Functional 90% of day. Update 04/2013: L/C 200/50 8x; Beta Blocker; ACE Inhib; Ginger; Turmeric; Creatine; Magnesium; Potassium. Doing well.
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