Hi Jappy,
Is Tramadol the only pain medication you are taking? My Neuro said that one (Ultram) is the only one I will not benefit from, taking with LDN. I looked at Dr. Bihari's website and it states the same thing.

Personally, I found the Ultram (Tramadol) lost it's usefulness years ago for me. I used it for back pain before and after back surgery. My now Neuro says don't take Ultram, it has warnings on it with the FDA. I haven't checked that out, but will immediately after I post this.

LDN Q & A info:

Can LDN be taken with other medications such as tranquilizers or chemotherapy? How about interactions with alcohol or tobacco?

LDN can be taken along with any other medication or substance, so long as it is not narcotic-containing. Naltrexone is a pure opioid antagonist and it will block the action of narcotics.

Some examples of narcotic-containing drugs are Ultram, (ULTRAM® =Tramadol ) morphine, Percocet, Duragesic patch and any codeine-containing medication.

How Does It Work?

LDN is another one of those “no one really knows how it works” drugs for MS. One theory is that it increases the body’s sensitivity to its own endorphins, or even do something that helps the body make more endorphins (the feel-good hormones). There is some evidence that endorphins reduce inflammation, as well as lessen negative sensations of pain, fatigue and depression.

Another theory suggests that LDN somehow reduces the production of free radicals, almost acting like an antioxidant.

My Neuro also said this:

Our body produces natural opioids (endorphins) as part of its survival
response to danger and injury. Because the medications of this class (LDN) work in the same way by increasing endorphins, they work very well in blocking pain

I have found that the LDN does indeed block many of my pain and sensory symptoms. I looked this up because I wanted to know about the pain medication I will have for my biopsy.

IMO, FWIW, You probably will have some withdrawal from the Ultram (Tramadol). Maybe 50% to 80% effective. Can you switch from the Tramadol to something else? Or wait out the withdrawal? Or even start on 1.50 of LDN for now?

The LDN should give you pain relief, but you just started on it. It may take a a week or two until you can get up to the 3.0 mg and be on that for two weeks or so, to benefit from the LDN's natural pain reliever effects.

What type of pain were you using the Tramadol for? - if you don't mind me asking?

I haven't needed anything but Aspirin for sickness or headache since on LDN. I hope it works the same for you. It may take time.


PS: While typing this.. I just got a call from the doctor doing my Biopsy 9-1. No medication will be shot into the skin, and no pain medication will be used by this doctor before or after.

He said it causes swelling of the tissue. He said I won't feel a thing. This is a different doctor than last time. No Asprin prior he said, LDN is okay. Yippee!