Oh Bob, I can't address the effectiveness of Methadone on PN, but I have witnessed...first had the devastation of methadone withdrawal and the dangers of respiratory failure. I lost two clients to methadone overdose and another to suicide do to as he explained..."If I would have known how horrible methadone was, I wouldn't have given up on heroin. I understand the difference between pharmaceutical and street drugs....I just worry someone using this incredibly addicting drug if they can possible use one less deleterious.