Although Requip has been effective for my RLS for maybe 3-4 years now, the real relief came in the absence of severe nocturnal leg/foot cramping, which left me leaping from bed whether I wanted to or not. Magnesium, potassium, etc., did not seem to help this cramping, but Requip has, and continues to be effective for both the restlessness and cramping. I am grateful, but am also grateful for your information about rotating the meds. That sounds like an excellent idea! Thank You. billie