Erin, There are lots of reasons for water retention. I agree with your neuro. Finding a cause is far more important than throwing a drug at a problem. Kidney problems can cause water retention. Renal artery stenosis or other arterial problems like peripheral artery disease can cause it.

When was the last time you had a chem panel? An ECG or echocardiogram?

It sounds like you are on a steady dose of Pred, however you are going every other day. Even that drop from 60 to 40 can cause signs of an adrenal crisis. That includes sweating and feeling hot. Maybe you need to be on a steady dose of Pred or you might need to come off of it (of course, if that's what doctors think). I know someone whose doctor had her do that every other day dose thing and she almost had an adrenal crisis.

You have to see someone right away. If your kidney function is tanking, that's dangerous. Having drugs to make your MG better is great but they don't come without huge risks.

I hope they can figure out what is going on. I'm sorry you aren't doing well.

Annie