Barbara, I wonder if it's the Pred that is making you feel "hyper" or awake. A lot of people can't sleep as well on Pred. I haven't taken Imuran so other people will have to help you out there.

Mestinon does not have a stimulant effect. In fact, I wake up in the middle of the night needing it to be able to sleep again.

When in doubt, talk to your neuro about all this.

Annie