Titre du document / Document title
Nocardia asteroides strain GUH-2 induces proteasome inhibition and apoptotic death of cultured cells
Auteur(s) / Author(s)
BARRY Daniel P. (1) ; BEAMAN Blaine L. (1) ;
Affiliation(s) du ou des auteurs / Author(s) Affiliation(s)
(1) Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, CA 95616, ETATS-UNIS

Résumé / Abstract
Many bacterial pathogens have the ability to induce apoptosis in their hosts. It was previously shown that Nocardia asteroides strain GUH-2, a Gram-positive facultatively intracellular pathogen, is capable of inducing the apoptotic death of dopaminergic cells in the murine brain and in PC12 cells, a rat cell line

http://cat.inist.fr/?aModele=afficheN&cpsidt=18539100

________________-


Nocardia asteroides: An Infectious Etiological Agent in Parkinson's Disease
Several studies suggest that Parkinson’s disease can either be familial or sporadic;
however, only five percent of the patient population is classified as the familial type. This
indicates that most cases of Parkinson’s disease are associated with exposure to
environmental factors. Chemical agents such as pesticides and the synthetic molecule 1-
methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) have been established as
dopaminergic neurotoxins that can be potential etiological factors for the disease. In
contrast to what is known about chemical agents, it is still not clear whether Parkinson’s
disease can be elicited by infectious microorganisms.

http://www.mcmp.purdue.edu/seminars/...suabstract.pdf