I would like to comment on the drug, Lisinopril.

I have very little experience with TBIs myself, but I do know alot about drugs. So when I see a drug question, here, I might show up with some input.

In the past two years new research is coming out on Lisinopril.
This drug's brand names were Zestril and Prinivil. It also comes with a diuretic--HCTZ --Hydrochlorothiazide.

It is not common to find NEW data on drugs that have passed patent times and become generic. So the data on lisinopril is special.

What has been found is that some of the ACE inhibitors (the family that this drug belongs to) cross the blood brain barrier and enter the brain. Lisinopril and Altace are ones that do. Vasotec (enalapril does not).
more here:
http://www.bestsyndication.com/?q=05...rs_disease.htm

There have been studies now on progression of Alzheimer's and now just recently on multiple sclerosis, that ACE inhibitors that enter the brain, reduce inflammation there.

Lisinopril is not metabolized by the liver, and is excreted whole.
It is also not bound to carrier proteins, which means it does not interact much with other drugs.

It does however over time deplete zinc. So it would be a good idea to take a mild zinc supplement.
The addition of the HCTZ increases nutrient depletions, mostly magnesium, potassium and thiamine Vit B1. Because ACE inhibitors increase serum potassium up to 15% above normal, the loss of potassium with the HCTZ portion may balance out. But I have seen some people get low potassium on the mixed 2 drug product. So if you eat poorly and develop leg cramping, report that to the doctor.

The most common side effect --and typically in the high dose range is dizziness. But all in all, lisinopril is easy to tolerate.

If you have any questions, feel free to PM me anytime.