If it were lots of people would have factitious elevated BUN...uric acid.
The effects of HCTZ are because of specific actions on the kidney.
Diuretics increase absorption of urate in the kidney.
Quote:
|
Use of loop and thiazide diuretics is associated with gout, as they induce hyperuricaemia by increasing urate reabsorption. However this is not necessarily a direct action of the diuretics. Rather hyperuricaemia occurs when diuretics produce sufficient salt and water loss as to result in volume contraction and it is the volume contraction that causes urate reabsorption at the proximal tubule[1]. Accordingly it is the patients base line urate status before introduction of any diuretic that appears to be important[2] with to date the exception of bumetanide. There is good evidence that this drug is actually uricosuric[3]. Accordingly there is a predictable dose response behaviour both with dose of an individual diuretic and the worsening of hyperuricaemia when combination therapy is used.
|
Melody's test results are not too out of range... the serum creatinine is normal. The doctor may overlook it all.
__________________
All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
************************************
.
Weezie looking at petunias 8.25.2017
****************************
These forums are for mutual support and information sharing only. The forums are not a substitute for medical advice, diagnosis or treatment provided by a qualified health care provider. Always consult your doctor before trying anything you read here.