Hi zipfed and Welcome.
I tried Avonex for one year, and Copaxone for 3 1/2 years. Between bad Flu-like side effects from "A" and liver enzymes rising quite high (I need my liver), and infections allowed by Copaxone to enter un-noticed, I stopped all MS meds in 2004. I was on nothing for 4 years and tried 'C" again for 14 days.

The side effects from "C" were worse then when I used it before. I don't know why. Something had changed. Last month I had a Dematofibroma removed from my thigh, the Dermatologist said the "C" could have caused it. It is still healing, but it was painful and itchy for over a year.

I guess my body does not tolerate the DMD's. They also did not help me. Or stopped working. I still relapsed very often. Some were acute and required IVSM to walk again along with the "C". So for 4 years I was not on any MS medication, as per my MS Specialist. We looked for a treatment plan.

For the last 8 months I have been on LDN, no DMD's for those 4 years, and I will never go off of it. It has changed my life for the better. So many improvements. I even found old residual symptoms leaving.

I was dx'd MS in 1981, symptoms doctors could see in 1978, but I had to "wait and see" in limboland for 3 years.

If you feel "C" is helping you, you can use Combo therapy and use both. It cannot be used with the interferons. The method of action of the interferons would conflict with LDN, IMO.

I hope this answers your question.