Hi. I am sorry of your struggles. Have you been to a neuro? Who rx the topomax? I would get into a neuro since the condition is changing.Mrs D gave very good advice but I wonder what bloodwork you have had? Have you had any tests done since this has been going on for so long? I think in terms of meds that everyone is different. I am on neurontin and it has helped though my pain is very high at leat progress. I just had an increase so am feeling ill but it usually the side effects wear off. I have been on meds that others have had side effects and I have not so it is key to stay in the moment. It may really help you and some side effects go away or the benefit is worth it.