i take 90 mg. every 4 hours, religiously. 6, 10 and 2. yes that means 2 a.m.. it wears completely off in 5 hours. one 60 mg pill does not usually completely control my symptoms. i tolerate it fairly well. occaisional g.i. complications but i've learned to deal with that. i consider it an equitable trade-off. seems to work best if kept at a constant level and it takes a half hour to a full hour to kick in if i let it wear off. i carry a full day's dosage with me in my work truck.