I had a discussion recently with my doctor about this.

He told me Gabapentin came first and Lyrica was an "upgrade." Why they work is unknown.

I've never taken Gabapentin. I tried Lyrica but it didn't help and I gained weight. I started Cymbalta - worked like a charm for a week. I stopped taking it when I got sick (unrelated). I'll be starting up on it again shortly - after I get past a certain event at work (after the shuttle lands).

Why Cymbalta works is unknown.

I usually just lurk here at PN. It's just the most recent extension of the MS I've had for 22 years.

Tom