Hi all - I need to take advantage of your collective wisdom and experience. Years ago, I was on Mestinon. It worked well for me - as long as I was in the bathroom. It was awful. It made my gut spasm and it wasn't pretty. After a rather embarrassing "accident" I gave up on Mestinon. [Fast forward 3 years] I have now been on steroids, Imuran, Cellcept, had IVIG and Plasma Pheresis and nothing is working. I'm so sick I can barely function. So I started looking online for drugs that I would take with Mestinon to mitigate the affect it has on my gut. I came up with several: Bentyl, Lomotil, Propantheline, Lubiprostone and Questran. I was hopeful one of those would work and allow me to try Mestinon again. I saw my Neuro yesterday and he said that I could not take ANY of those drugs because they are all contra-indicated for MG.

I really need to find a way to try Mestinon again. Do any of you have any suggestions for dealing with the gastric side effects of this drug?

Desperate for answers. Martha