Hi, I have found a direct correlation between taking a bit too much levodopa and severe, painful, muscle spasms. They have been in my ankle, knee, hip and yes, shoulder. I don't think everyone experiences this, But I DID have a neurologist insist that PD was not painful. Ahhh if he could have (tried) to walk a mile in my shoes the day I could not even step down on my foot, I guess he was right, because it wasn't the disease just the drug he gave me, huh? Might be worth looking into FG