A few twitter comments from yesterdays ECTRIMS PML Plenary Session

http://twitter.com/neurologique

Plenary: Natalizumab treated patients who get PML have very low CD 4+ T cells and dendritic cells. Antigen presenting cells are depleted.

Plenary: The MRIs from the first post-marketing German PML patient was released yesterday and shown at plenary on PML.

Plenary:… Reduced iATP is more sensitive for detecting those at risk for PML and opportunistic infections (better than CD4).

Plenary:..Question was: iATP (intracellular ATP) is nonspecific and wide dispersion even in healthy individuals.

Plenary:…Answer:Agrees-doesn’t explain PML but is independant of CD4 count.