I recently received results for my daughter from EnteroLab's "Gluten Sensitivity Stool and Gene Panel Complete," and our nutritionist suggested I ask my questions about them here. She is 18-mon and from birth has struggled with digestive problems (LONG story), including MSPI & difficulty w/ all carbs/starches. She trialed wheat for maybe 2 wks but never had much. These test results are just one more piece in the puzzle for us.

I'm curious what you see as the implications of her "fecal anti-tissue transglutaminase IgA" being elevated. (Normal is < 10, hers was 88.) From reading on-line, it looks like when this is in the blood it's a trigger for drs to do a biopsy for Celiac. Does it point to possible Celiac when in the stool, too?

Her "fecal anti-gliadin IgA" was also elevated. (Normal is <10, hers was 189.)

As for her genes, they were HLA-DQB1*0202 and HLA-DQB1*0503 (a DQ1 gene). According to EnteroLab's interpretation, she didn't have the two main HLA-DQB1 genes predisposing her to celiac sprue (HLA-DQB1*0201 or *0302), but did have two that predispose to gluten sensitivity (a DQ1 and a DQ2 other than HLA-DQ1*0201), and the HLA-DQ2 gene can be associated with celiac sprue in rare cases. Do you have any other thoughts on the genes?

She has been off gluten for weeks now & I intend to keep her gluten-free.
I don't have any inclination to have her biopsied at this point (have no desire to feed her wheat in advance), although am happy to listen to your advice. I'd be curious to know what you think the chances are she has Celiac's and not simply a gluten sensitivity.

Finally, my husband, my son, and I have no apparent problems digesting gluten, but given my daughter's genes results I'm thinking probably we should be tested, too. Do you think a simply gluten sensitivity test (anti-gliadin IgA) is sufficient? Are there advantages to also getting the anti-tissue transglutaminase IgA test? Or the entire panel?

Thanks.