Glad you have "pulled off the switch" finally.

i have taken zoloft lots, and lots of it (up to 200) and also in small doses, been on, been off, increased and decreased with mood cycles. good med for me.

the initial titration (25 mg/wk) is good - reduced side effects. and in the case of mixed episodes, very prudent as it is an activating drug.

clinical changes observable 2 - 6 weeks from time you are on a therapeutic dose. depends on individual. doc may yet decide to increase dosage further during that time, per his judgement.

zoloft takes 1 week to reach steady state. even at regime, when you are seeing benefit from it, if an increase is clinically required, the overall effect of the increase will not be 100% observable before that 1 week period. to avoid excessive doses, and possibly dangerous side effects the dose should not be modified more frequently than 1 week at a time.

100 is good therapeutic dose for starters. can increase to 125/150 if nec.

max is about 200mg...

but if you are mixed still... your pdoc will surely be very judicious about giving you that much.

if increasing dosage, from now on, be vigilant for grinding/clenching of teeth, excessive (increased) muscle tension (or exacerbation of your pain sx), and headache, and if present report it to your doc right away for safety.

if there is flushing, hyperthermia, fever, excess sweating, myoclonus, headache or other questionable symptoms, go to an urgent care center. high doses can cause serotonin syndrome which can be fatal.

((( hugs )))

~ waves ~