I WAS ADVISED THAT QUININE CAN CAUSE SOME PROBLEMS WITH THE HEART. I HAVE SYMPTOMS OF IT. LYRICA ACTUALLY HELPS IT. THAT IS RLS. MY LEGS GERK AND TWITCH ON THEIR OWN. I TAKE THREE TO FOUR CONCERTA PILLS AND ONE TO TWO PROVIGIL TO KEEP ME AWAKE. AND SOMETIMES I STILL DRAG..AT LEAST MOST OF THE TIME.