SAMe is only a methyl donor. It cannot make any neurotransmitters without the substrate being available to attach the methyl groups to.
Tryptophan requires B6 to be converted to serotonin.
And serotonin requires methylcobalamin (methyl B12) to convert to melatonin.
Tryptophan does not easily cross the BBB, but 5-HTP does.
Other amino acids compete for the transporter across the BBB.
Taking tryptophan spaced away from other protein foods, will allow it to cross the BBB more easily. High insulin levels facilitate this too.
That is why 5-HTP may cause more side effects, as it crosses easily.
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All truths are easy to understand once they are discovered; the point is to discover them.-- Galileo Galilei
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Weezie looking at petunias 8.25.2017
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