Methotrexate is a mitochondria poison. It used to be used as a chemo anticancer treatment. The use for inflammatory disease is somewhat different, but the drug effects remain the same.

http://www.mitochondrial.net/showabs...ondrial+damage

Since the mitochondria are the energy factories for our bodies' cells, damage to them, will damage tissue/muscle over time.
The trade-off is of reducing inflammatory response, vs killing the beneficial cells. One side effect of methotrexate is muscle weakness.

I put up a video on the vaccine thread here, yesterday. Dr. Cannell explains how Vit D prevents the body from attacking itself during viral infections. Since Vit D has been found very helpful for MS (an autoimmune disease), it is becoming more obvious every day that people with ANY autoimmune problem, who are making cytokines in excess which are attacking themselves, should have Vit D tested and take adequate doses to bring them up to normal levels.

Here is the video again:
http://www.youtube.com/watch?v=--NqqB2nhBE

While no studies show use of acetyl carnitine with methotrexate, carnitine is useful to prevent chemo cell damage in normal cells.