I don't know how long you have been on your meds, but if they are new, I can offer some hope. My research has found that your body slowly adapts to the medication and can eventually do away with the side effects. Everyone's body is different, so you will have to pay close attention to your body's own signals. The down side, of course, is that as you become used to the meds, they decrease in effectiveness- hence my need for increase in my hydrocodone, but at least you can function. I'm not a big person (5'8 and 145 lbs), but my body can handle medications very well. I'm on Neurontin, Tramadol, Cymbalta, and Hydrocodone 10/325, and I can drive on all of it with no problems at all. It only took about a week for the Tramadol to stop giving me any mental effects at all (although it still keeps me awake if I try to take it before sleeping). The Hydrocodone took a few weeks- I started at 7.5/750 and when my docttor increased it, I had already adapted, so no mental feelings at all. I just didn't take the meds when I was going to drive until I adapted. Keep your doctor in the loop, and hopefully he/she can help you find pain relief and still be mobile. Good luck!!