Hi DM! I didn't realize the subject was so confusing until you spelled it out!! LOL!! In my case the turning point was when the new and old symptoms of a relapse, never went away. Now I don't seem to have major exacerbations anymore, but at times I feel extra "carpy" -- weaker, more dizziness, nauseous, etc. My legs no longer work to walk, so I don't know if they're affected. I have a standing script with my neuro for Decadron pills if this happens and lasts too long. I'm allergic to solumedrol and my veins are shot for IV's -- hence the pills. Decadron is a steroid too. Anyway most of these symptoms are always here, but not as pronounced.

I have been taking LDN for a few years now and my neuro said they certainly must be helping as I should be in worse condition for the number of years I've had MS -- 19 diagnosed and probably 14 before that. For those who don't know "my story", I do use a powerchair all the time, but can stand for a couple minutes at the sink, transfer to regular chairs, toilet, and live alone. So even if you go SPMS, it doesn't necessarily mean it's all bad!!

Now you're probably REALLY confused!!!