About 7yrs ago my knees started getting stiff-then my balance was off - these did not remit. I was dx 10/1988. I only had 1 MRI in 1988 and it was lost - next one was after stiff knees showing some brain lesions and 1 main one in the spine. I had no sx for 13 1/2yrs following dx-so original sx remitted for 13 1/2yrs (no meds) and then 7yrs ago put on baclofen. Neuros have not put a name on my ms but appears to be spms. Thank G-d progression has halted for me since being on Ty.