Thanks for all the thoughtful replies. This is the first time I have felt energetic enough to check the postings this week.

I may try Sinemet CR for the first time tomorrow (50/200)- the Specialist advised me to take it first on a day I am not working, as the results are unpredictable. I am thinking of taking it with a tab of my usual 10/100 (reg) Sinemet @ 6:15, an hour after breakfast.

I take the Sinemet almost 2 1/2 hrs after I get up because I feel good when I get up- my theory is that I am running on naturally-replenished-while-I slept dopamine. Perhaps I will try taking the Sinemet first thing when I wake up, just to see if that keeps me on more evenly.

I totally agree with all the comments about not letting myself get behind on being "on.' This week, I have been taking the 10/100 Sinemet every 2 1/2 hrs, instead of the usual 3 hours-- and using a tsp of Zandopa (=~100 l-dopa) to supplement 3 of the doses. Definetley feel better, although my annoying left foot toe curling/ knee spasms continue.

This last visit to the Spec made me aware of two things:

1 what they are really for is adjusting medications. Period.

2 they don't have time in advance of the appointment to look at carefully prepared, detailed yet concise e-mail files sent them 10-14 days in advance. I sent the files with a request to look them over and comment on any suggestions he & his nurse have on tweaking the meds dosing, schedule and supplements.

Silly me to have expected such a thing! I think I will post my file with the Ask a Nutritionist on the NPF site.

I do give the Spe.c credit for honestly answering my questions about minocycline, Zonisamide, Glutathione, as well as my use of Ativin for PD related anxiety. (most of the time, the honest answers are "We don't know" "there is no scientific evidence of its usefulness," etc....)

Thanks to all of you. I will let you know what my experience with Sinemet CR is like.

George