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The only thing that came out abnormal was a positive gliadin reading of 38. My neuro thought I might have Celiac so I went to a GI specialist. I had an endoscopy and the results were negative for celiac.
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Looks like there was an isolated positive antigliadin antibody... but that is enough to show gluten sensitivity.. and warrants a gluten free diet.
Is the anti-tTG6 antibody test available commercially? I thought it was only in research phases still... because I'd like to have my gluten consuming daughter tested for it when it is available. Is it only found in those w/ gluten ataxia, or with any neurological involvement? I'm not quite clear on that either. Dr. Hadjivassiliou has done so much to advance the understanding of gluten related neurological disease! I hope one day there will be more from him on HLA DQ1 ... because too much emphasis is placed upon HLA DQ2 and HLA DQ8 imo. His previous work has shown that 20% of those with gluten related neurological disease
do not have the main celiac genes, but HLA DQ1. I cringe everytime celiac/gluten sensitivity is RULED OUT because of the absence of the main genes.
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RESULTS: Whereas the development of anti-transglutaminase 2 IgA is linked with gastrointestinal disease, an anti-transglutaminase 6 IgG and IgA response is prevalent in gluten ataxia, independent of intestinal involvement. Such antibodies are absent in ataxia of defined genetic origin or in healthy individuals. Inhibition studies showed that in those patients with ataxia and enteropathy, separate antibody populations react with the two different transglutaminase isozymes. Furthermore, postmortem analysis of brain tissue showed cerebellar IgA deposits that contained transglutaminase 6. INTERPRETATION: Antibodies against transglutaminase 6 can serve as a marker in addition to human leukocyte antigen type and detection of anti-gliadin and anti-transglutaminase 2 antibodies to identify a subgroup of patients with gluten sensitivity who may be at risk for development of neurological disease.
Autoantibodies in gluten ataxia recognize a novel neuronal transglutaminase.
PMID: 18825674 Sept 2008
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From "Gluten sensitivitiy as a neurological Illness" by M Hadjivassiliou, R A Grunewald, G A B Davies-Jones:
"Within the group of patients with neurological disease and gluten sensitivity (defined by the presence of anti-gliadin antibodies) we have found a similar HLA association to that seen in patients with CD: 70% of patients have the HLA DQ2 (30% in the general population), 9% have the HLA DQ8, and the remainder have HLA DQ1. The finding of an additional HLA marker (DQ1) seen in the remaining 20% of our patients may represent an important difference between the genetic susceptibility of patients with neurological presentation to those with gastrointestinal presentation within the range of gluten sensitivity."
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