I did ok with Avonex but not so much with Rebif. It caused very bad depression and anxiety.

Tell the doctor what you just wrote. If it's making things worse, why suffer for six months? That doesn't make sense to me.

I just read somewhere that if you're in an active flare, you shouldn't start Tysabri, that it can make things worse.

Have they mentioned Novantrone followed by Copaxone? I think that has shown good results with people with particularly aggressive MS.

Feel better soon.