Quote:
Originally Posted by mhr4
I don't think there is an upper limit established for B12. Does anyone know?
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You are correct... no upper limit established.
There are studies on PubMed from Japan that used 40 MILLIGRAMS per dose in fact for an MS study. I don't recommend that, of course.
However, cyano version of B12 is not metabolized well in some people...some cannot handle the cyanide portion, of this synthetic version.
That is why using methylcobalamin (or hydroxycobalamin) is safer--hydroxy costs more however-- is the best way to go.
The methyl version is the exact same as the active version in the body.
The only reported side effects for high dose B12 (and 1000mcg oral is not high dose since it is not all absorbed)... is acne. And that is with the cyano type.
There is a new oral coming out ...here is the link to it:
http://www.emisphere.com/oral_vitamin_b12.html
Don't know what type it is yet, however. Expect it to cost more than the methyl that many of us use already.
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