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Originally Posted by gabbycakes Mike, First, let me say thank you for the time and effort you put in to your post. They are extremely detailed and very informative and I truly appreciate it. I have had 3 - 5 day inpatient ketamine infusions with boosters. I worked with doctors in NYC and Dr. Schrwartzman. I had good results. Without getting into a book of explanation the ketamine treatments settled all of the symptoms on the scale I would say I was at an 9 when I started and today I would say I go up and down from a 2 to a 5 based on the weather and other factors. My question to you is have you ever come across any studies of the effects, long term from the ketamine. I have had some strange things happen, nothing really serious, but just change. Example I always had good healthy teeth, now I am at the dentist for some reason or another for i.e cavities, root canals, extractions etc, every 3 months. My dentist thinks the ketamine damaged the PH in my system in turn effected my teeth. If you have any direction you can point me in to find out more on this subject I would appreciate this. I know Parke-Davis makes ketamine so I am trying to contact them to get some solid information. Or at least I think it's Parke-Davis. Thank you, Gabbycakes

Abstract
The purpose of this study was to examine possible peripheral mechanisms for the reduction of propofol injection pain by the addition of ketamine. We hypothesised that pH changes associated with the addition of ketamine to propofol decrease propofol-induced pain on injection. We compared the efficacy of intravenous ketamine pretreatment under tourniquet with ketamine added to the propofol. In the pre-treatment group, patients received ketamine 10 mg in a total volume of 1.0 ml with 0.9% saline (n = 94; Group P) under tourniquet for 30 seconds before administration of propofol after release of the tourniquet. In the mixture group, propofol 9 ml was mixed with ketamine 10 mg in 0.9% NaCl 1.0 ml (n = 94, Group M). Pain was assessed with a four-point scale: 0 = no pain, 1 = mild pain, 2 = moderate pain, 3 = severe pain at the time of propofol injection. The pH of propofol, ketamine and a range of propofol-ketamine mixtures were also measured. Forty-eight patients (51%) in Group P complained of pain on injection compared with 28 patients (30%) in Group M (P = 0.005). The pH of the 1% propofol-ketamine mixture was 5.84 while 1% propofol had a pH of 7.86. Our results support pH changes as a more important cause for the decrease in propofol injection pain with the addition of ketamine to propofol than a peripheral effect of ketamine.

PMID: 19681415 [PubMed - indexed for MEDLINE]