I discussed this with my neuro and internist and they both agreed it would be worth a try. I agree that the mestinon is probably the cause of the overactive bladder, but I think mg also affects the uretha (sp?). I didn't have any problems in this area until I started haveing wierd problems which turned out to be mg. I have had nothing but problems for the last 10 years. When the mg is under better control, the problem is not near as bad as it is when I have to take 120 of mestinon every 3 hours (which I am currently doing).

The doc at Vanderbilt is very familar with mg (which kinda surprised me) but she has a PHD in microbiology as well as being a specialist in urology. I'm going to send her an email and get an answer to the concerns about botox for mg patients and will post here once I have an answer.

FYI, I thought it was kinda neat how they decided which doc I should see at Vanderbilt. My local urologist sent a referral to the VB urology clinic and the docs sat around a table and reviewed all the referral files. The doc who was best suited to handle each case was assigned that particular case. My doc handles most of the immune compromised patients and from my conversation with her and her nurse, it is very apparent they are familiar with mg.