This is a great question and one I'm wondering about as well. Right now I'm thinking you should take as little as you can, and still function and be comfortable. That's because I don't want any more dyskinesia than I have to have later on.

On the other hand, many think that you should keep the level of dopamine as steady as possible to decrease dyskinesia So right now, my "more on" and "less on" periods are probably not ideal. (I'm not sure I can really call what I experience being "off", I'm just not as good as the meds wear off after three or four hours.)

Right now I take three doses a day, and try to avoid other people between 12:00 and 1:00 or so. Probably if I took four doses, I wouldn't have those less functional times. I see my MDS at the end of Jan. to talk about this, but am looking forward to reading what others on this forum say. Sometimes I think the body of knowledge on this forum is greater than his!